ASSESSING SERVICE AND TREATMENT NEEDS OF YOUNG PEOPLE WHO USE ILLICIT AND NON-MEDICAL PRESCRIPTION DRUGS LIVING IN NORTHERN ONTARIO, CANADA [VERSION 2; PEER REVIEW: 2 APPROVED]

Background: The use of illicit and prescription drugs for non-medical purposes among youth and young adults living in Northern Ontario communities is a major public health concern.This problem is amplified in that there is insufficient knowledge on the types of services and treatment centers available for and utilized by young people with substance

AIM: To investigate the inhibitory effect of the combined use of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and oridonin on choroidal melanoma cell lines, and to explore its underlying mechanism.METHODS: MUM-2B and Slings C918 cells were treated with different concentrations of TRAIL and oridonin, and MTT assay used to evaluate

Situated within the context of a soft ground foundation at an iron ore mining site, this study investigates the impact of substantial surcharges on the settlement of such foundations and Earrings the adjacent infrastructure.By employing the finite-difference numerical software FLAC3D 6.0, a series of three-dimensional simulations were conducted to

BACKGROUND: An imbalance between overwhelming inflammation and lymphocyte apoptosis is the main cause of high mortality in patients with sepsis.Baicalin, the main active ingredient of the Scutellaria root, exerts anti-inflammatory, anti-apoptotic, and even antibacterial properties in inflammatory and infectious diseases.However, the therapeutic eff